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酒精成癮的遺傳表觀調控

發布者:文明辦發布時間:2019-06-27瀏覽次數:322


主講人:劉贇 復旦大學研究員


時間:2019年6月29日16:00


地點:三號樓332會議廳


舉辦單位:數理學院


主講人介紹:劉贇,復旦大學,基礎醫學院生物化學與分子生物學系,研究員,博士生導師。研究方向主要集中于運用表觀遺傳組學的方法,研究人類復雜疾病的成因,以及致病的生化機理機制。2013  年,運用全基因組 DNA 甲基化譜的手段,第一次揭示了 DNA 甲基化對類風濕關節炎病的發生的關系。這項工作發表于 Nature Biotechnology  上。除此以外,課題組在此領域的其它學術成果還被發表在 Nature Genetics、Immunity、The American Journal of  Human Genetics 等國際第一流的學術科研期刊上。在過去 5 年中,論文共被他引 1500  多次,所作出的學術成果受到包括紐約時報在內的多家主要媒體廣泛報道。擔任 Nature Communications、PLoS  ONE、Epigenetics、Arthritis Research and Therapy、Neoplasma 等雜志審稿人。2009 年獲 Johns  Hopkins 大學 32nd Young Investigator Award 獎項。


內容介紹:酒精成癮是一個嚴重的社會學問題,其產生與遺傳與環境因素有著密切的關系。為了探討表觀遺傳修飾在酒精成癮中的作用,通過整合人死后腦組織樣本及血液樣品的遺傳、表觀遺傳修飾信息,以及人腦影像學、藥物基因組學和小鼠模型,我們研究了DLGAP2基因在飲酒、酒精依賴和治療后復發風險中的作用。

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